Pandemic Influenza – Purpose
May 11, 2009
PURPOSE
To educate healthcare professionals about the causes, risks and means of containment of pandemic influenza.
Pandemic Influenza – Outline
May 11, 2009
What Is Pandemic Influenza?
II. Seasonal Influenza
III. Modes of Transmission of Influenza
a. Direct Contact
b. Droplet
c. Airborne (Droplet Nuclei)
IV. Influenza Types and Subtypes
a. Influenza Type A
i. Antigenic Drift and Shift
b. Influenza Type B
c. Influenza Type C
V. Strains
VI. Swine Influenza A (H1N1) and Avian Flu
VII. Spanish Flu (1918-1920)
VIII. Cytokine Storms
IX. Bacterial Pneumonia the Probable Culprit
X. Pandemic Severity Index
XI. Asian Flu (1956-1958)
XII. Hong Kong Flu (1968-1969)
XIII. Potential Impact of a Pandemic
XIV. Pandemic Prevention and Control
a. Influenza Vaccines
b. Anti-viral Drugs
c. Antibiotics and Bacterial Vaccines
d. Non-pharmaceutical Measures
e. Role of the Healthcare Provider
f. Monitoring of Healthcare Workers
XV. Pandemic Preparation
Pandemic Influenza – References
May 11, 2009
REFERENCES AND RESOURCES
Bloomberg News article, Scientists Move Closer to Understanding Flu Virus Evolution (August 2006).
Brundage. J.F. and G.D. Shanks, “Death from Bacterial Pneumonia during 1918-19 Influenza Pandemic”, Emerging Infectious Diseases (August 2008).
Fidler, David, “Progress and Problems with Global Health
Governance”, Global Public Health (2007).
Kawaoka, Y (ed.), Influenza Virology: Current Topics. Caister Academic Press (2006).
Lemon, Stanley M. (ed.), The Threat of Pandemic Influenza: Are We Ready? National Academies Press, p. 66 (2005).
Markel, Howard, MD, et al, “Nonpharmaceutical Interventions Implemented by US Cities during the 1918-1919 Influenza Pandemic”, JAMA. 2007; 298:644-654.
Morens, D.M., et al, Predominant Role of Bacterial Pneumonia as A Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness. The Journal of Infectious Diseases DOI: 10.1086/591708 (2008).
Nicholls, H., “Pandemic Influenza: the Inside Story”. PLoS Biol. 4 (2): e50 (February 2006).
Price-Smith, Andrew, Contagion and Chaos, Cambridge, MA: MIT Press (2009).
Roos, Robert and Lisa Schnirring, “HHS Ties Pandemic Mitigation Advice to Severity”, University of Minnesota Center for Infectious Disease Research and Policy (CIDRAP) (February 2007).
Taubenberger, J. and D. Morens, “1918 Influenza: the Mother of All Pandemics”, Emerging Infectious Diseases, 12 (1): 15–22 (2006).
www.cdc.gov/ncidod/diseases/flu/fluvirus.htm
www.clinicaltrials.gov
www.hhs.gov/nvpo/pandemicplan/index.html
www.nih.gov
Pandemic Influenza – Objectives
May 11, 2009
OBJECTIVES
Upon completion of this course, the learner should be able to:
· Define pandemic influenza
· List 3 modes of transmission of influenza
· List the 3 types of influenza virus
· Discuss the difference and implications of antigenic drift and shift
· Identify the 3 major influenza pandemics of the 20th century
· Explain the role of cytokine storm in susceptibility to influenza
· Explain the role of secondary infection by bacterial pneumonia
· List 3 means of pandemic control





